%0 Journal Article %T Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in rats %A Jiang Nai-Chang %A Gao Lie %A Chen Chan %A Pan Ya %A Liu Di-Cheng %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in rats %K %X Graded injections of argipressin (Arg, 150, 300, and 600 ng/1.5 microliters CSF, 2 min) into the medial amygdaloid body in anesthetized rats produced a dose-related increase in the mean arterial pressure and heart rate (Maximal delta MAP = 2.9 +/- 1.5 kPa, Maximal delta HR = 67 +/- 38 bpm), which lasting > 40 min at 600 ng dosage. Naloxone (15 micrograms/15 microliters CSF) injected into the lateral ventricle blocked the cardiovascular responses to Arg. These results suggest that Arg exerts a central action on the cardiovascular system via the opioid in the lateral ventricle. %U http://www.chinaphar.com/article/view/8718 %V 14 %N 2 %P 118-120 %@ 1745-7254