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Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in rats

   
@article{APS8718,
	author = {Nai-Chang Jiang and Lie Gao and Chan Chen and Ya Pan and Di-Cheng Liu},
	title = {Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Graded injections of argipressin (Arg, 150, 300, and 600 ng/1.5 microliters CSF, 2 min) into the medial amygdaloid body in anesthetized rats produced a dose-related increase in the mean arterial pressure and heart rate (Maximal delta MAP = 2.9 +/- 1.5 kPa, Maximal delta HR = 67 +/- 38 bpm), which lasting > 40 min at 600 ng dosage. Naloxone (15 micrograms/15 microliters CSF) injected into the lateral ventricle blocked the cardiovascular responses to Arg. These results suggest that Arg exerts a central action on the cardiovascular system via the opioid in the lateral ventricle.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8718}
}