@article{APS8717,
author = {Jing-Shan Shi and Bin Huang and Qin Wu and Ru-Xian Ren and Xiao-Long Xie},
title = {Effects of rhynchophylline on motor activity of mice and serotonin and dopamine in rat brain},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {2},
year = {2016},
keywords = {},
abstract = {Rhynchophylline (Rhy) reduced the spontaneous motor activity and enhanced the sedative and hypnotic effects of sodium pentobarbital in mice. The effects of Rhy on serotonin (5-HT) and dopamine (DA) concentrations in rat brain, and the release of 5-HT and DA from the regional brain slices were studied by a fluorescence detector. Rhy increased the 5-HT content in the hypothalamus and cortex, but reduced the DA concentrations in the cortex, amygdala, and spinal cord. Rhy promoted the release of endogenous DA from 4 brain regions. The release of 5-HT was increased in 2 brain regions and decreased in hypothalamus slice. However, Rhy inhibited the release of both 5-HT and DA evoked by high potassium.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8717}
}