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Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmia in hearts of rats

  
@article{APS8695,
	author = {Yu-Long Li and Shao-Xuan Fu and Yun-Shan Li},
	title = {Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmia in hearts of rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {m-Nisoldipine (m-Nis) or nisoldipine (Nis) (iv or perfused 10 min prior to coronary artery ligation) prevented reperfusion-induced arrhythmias in anaesthetized rats and Langendorff hearts of rats. m-Nis or Nis also reduced the contents of nonesterified fatty acids, the level of cell calcium, and free radical formation in the myocardium from the reperfused area. In conclusion, m-Nis or Nis prevents reperfusion-induced arrhythmias by regulating the metabolism of nonesterified fatty  acids, lowering cell calcium and inhibiting free radical formation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8695}
}