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Specific lesion in habenular nucleus induced by the intraventricular injection of monosodium glutamate in mice

   
@article{APS8688,
	author = {Guang-Jian Wang and Hong-Ju Cheng and Xin-Sheng Xiao},
	title = {Specific lesion in habenular nucleus induced by  the intraventricular injection of monosodium glutamate in  mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Lateral  cerebro-ventricular injection of monosodium glutamate (MSG) in adult mice specifically damaged the bilatcral habenular nucleus but spared other circumventricular  organs. The habenular nucleus lesions produced by MSG were dose-dependent and  irreversible. A high dose of MSG (350 ug/20 ul) induced convulsions in up to 95.8 % of the mice. but these convulsions were reversible and most of the mice survived. It is suggested that lateral cerebro-ventricular injection of MSG may be a suitable animal model to study the functions of the habenular nuclcus.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8688}
}