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Study on antidotes of homoharringtonine

	author = {Rui-Ting Chen and Zhi-Xiang Lu and Jing-Li Cheng and Bin Xu},
	title = {Study on antidotes of homoharringtonine},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {In 38 normal mice after ip homoharringtonine (HHT) 2 mg/(kg-d) x5 d with the observation period of 7 d. about 50% of mice died. HHT in combination with glycine or monoammonium glycyrrhizinate (MAG). batyl alcohol cepharanthine. astragalus polysaccharides (APS), polysaccharides of Acanthopanax senticosus (PAS), ginsenoside, chlorpromazine increased the mortality of mice. EDTA-Na and razoxane had no influence on the toxicity of HHT. HHT and sodium phenobarbital (SPB) injected simultaneously to mice also increased the mortality of mice. When SPB was administrated 3 d before HHT, the toxicity of HHT diminished. This regimen showed no marked influence on the antitumor activity of HHT at the dosage of l mg/kg.},
	issn = {1745-7254},	url = {}