@article{APS8678,
author = {Rui-Ting Chen and Zhi-Xiang Lu and Jing-Li Cheng and Bin Xu},
title = {Study on antidotes of homoharringtonine},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {5},
year = {2016},
keywords = {},
abstract = {In 38 normal mice after ip homoharringtonine (HHT) 2 mg/(kg-d) x5 d with the observation period of 7 d. about 50% of mice died. HHT in combination with glycine or monoammonium glycyrrhizinate (MAG). batyl alcohol cepharanthine. astragalus polysaccharides (APS), polysaccharides of Acanthopanax senticosus (PAS), ginsenoside, chlorpromazine increased the mortality of mice. EDTA-Na and razoxane had no influence on the toxicity of HHT. HHT and sodium phenobarbital (SPB) injected simultaneously to mice also increased the mortality of mice. When SPB was administrated 3 d before HHT, the toxicity of HHT diminished. This regimen showed no marked influence on the antitumor activity of HHT at the dosage of l mg/kg.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8678}
}