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Effect of oridonin on cell-free DNA synthesis in vitro

	author = {Ying Li and Tan-Mu Zhang},
	title = {Effect of oridonin on cell-free DNA synthesis in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Oridonin  is  an  antitumor agent isolated from Rabdosia mbescens Hemsl. The DNA synthesis system was sensitive to oridonin in a concentration-dependent manner.  When the system was exposed to oridonin 40 ltg/ml for 60 min, the DNA synthesis was inhibited by 62.5%. This inhibition was not reversed by increasing the DNA concentration. The preincubation of oridonin with partially purified DNA polymerase II of Ehrlich ascites  tumor cells produced a stronger inhibition, but that of oridonin with DNA or deoxynucleoside triphosphates did not. The inhibitory rates of oridonin 40 ltg/ml were 47 and 78% in the groups preincubated without and with oridonin, respectively. These results suggest that oridonin exerts an inhibitory action on DNA polymerase II.},
	issn = {1745-7254},	url = {}