@article{APS8664,
author = {Lei-Ming Ren and Yun-Shan Li and Shao-Xuan Fu and Chun-Jing Jin},
title = {Cardiovascular action of m-nisoldipine in anaesthetized rabbits and guinea pigs},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {5},
year = {2016},
keywords = {},
abstract = {In anaesthetized rabbits, the effects of iv m-nisoldipine (m-Nis) or nisoldipine (Nis) 10 vg/kg with respect to decreasing blood pressure were equally potent, however, the depression of heart contractility induced by m-Nis was weaker than that by Nis. Diastolic blood pressure began to fall 20 min after m-Nis 90 vg/kg was administered intraduodenally, with the depressing effect being longer than 2h. In vitro m-Nis inhibited KCl-induced contraction of the rabbit aortic strips, and the activity was not affected by exposing the drug to light for 24 h. m-Nis failed to affect noradrenaline-induced contractions of the same preparation. m-Nis l, 5 yg increased the coronary blood flow significantly in guinea pig Langendorff heart preparations, while bheart contractility was slightly depressed.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8664}
}