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Negative chronotropic and inotropic effects of Panax notoginseng saponins

	author = {Jie-Xiong Wu and Jun-Xiu Chen},
	title = {Negative chronotropic and inotropic effects of Panax notoginseng saponins},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {The automatic beating rate of guinea pig isolated  right  heart  atrium was slowed down and the positive chronotropic effect of CaC12 or isoprenaline was attenuated by Ponox notoginseng saponins (PNS) 1-3 mg/ml. The force of contraction of isolated left atrium and the positive inotropic effect of CaCl2 or isoprenaline were inhibited by PNS l-6 mg/ml. The inhibitory effects were dose- and frequency-dependent. Verapamil showed a similar effects to PNS. The electrophysiological study of transmem-brane potential of isolated right papillary muscle cells  revealed  that both the plateau phase and duration of the action potentials were shortened by PNS l mg/ml. The results indicate that PNS is probably a calcium antagonist similar to verapamil.},
	issn = {1745-7254},	url = {}