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Central regulation of intraocular pressure and cardiovascular apparatus with clonidine in conscious rabbits

   
@article{APS8636,
	author = {Dante De Santis and Michele Lisa and Vincenza Susanna and Liberato Berrino and Anna Rita Romano and Savino Chieppa and Emilio Marmo},
	title = {Central regulation of intraocular pressure and cardiovascular apparatus with clonidine in conscious rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Effects of clonidine on intraocular pressure (IOP), arterial blood pressure (BP) and heart ratc (HR) were cvaluated in normotensive conscious rabbits. Ocular and arterial hypotension and sinus bradycardia induced by intracerebroventricular (icv  third ventricle) clonidine (0.1-5 vg/rabbit) were reduced by icv yohimbine ( 1O vg/rabbit) , naloxone  ( 4 vg/rabbit) ,  bicuculline (2.5 vg/rabbit),  acetylsalicylic   acid    (100 Ug/rabbit)  or  flunoxaprofcn  (100 vg/rabbit).  Our results suggest that aradrenerg opiateic,  peptidergic,  GABAergic and prostaglandin systems are involved in ocular and cardiovascular effects induced by clonidine and that central nervous system is involved in the regulation of IOP.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8636}
}