@article{APS8633,
author = {Xiao-Yong Hao and Ze-Hui Gong and Bo-Yi Qin},
title = {Effects of huperzine A on cholinesterase isoenzymes in plasma of mice and dogs},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {4},
year = {2016},
keywords = {},
abstract = {Using polyacrylamide gel electrophoresis (PAGE). 8 and 4 cholinesterase (ChE) isoenzymes were separated from plasma of mouse and dog respectively. Huperzine A showed a higher selective inhibition of acetylcholinesterase (AChE) isoemzymes; but had little or no inhibition of butyryl cholinesterase (BuChE). TIDC exhibited strong inh ibition of AChE and BuChE isoenzymes either. Recovery rate of AChE isoenzymes inhibited by huperzine A and TIDC in dog plasma is quite the same. but the recoveries of BuChE isoenzymes inhibited by TIDC were very slow, as the recovery rate of AChE inhibited by huperzine A and TIDC in 4h were 79 and 65%, while that of BuChE were 100 and 0%, respectively. Huperzine A is very potent AChE inhibitor. TIDC has no strict selectivity to AChE and BuChE. but it combines more tightly to BuChE than to AChE.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8633}
}