%0 Journal Article
%T Effect of ohmefentanyl injection to the region of nucleus tractus solitarius on discharge of phrenic nerve in rabbits
%A Zhou Jie
%A Zheng Wei-Jun
%A Chi Zhi-Qiang
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Effect of ohmefentanyl injection to the region of nucleus tractus solitarius on discharge of phrenic nerve in rabbits
%K 
%X OhmefentanyI,N-I-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperdyl-N-phenylproanamide. is a potent analgesic first synthesized in our institute. Its main side-effect is respiratory inhibition. The discharge frequency of phrenic nerve was depressed about 50% by ohmefentanyl 0.02 vg/kg injected into the region of the nucleus tractus solitarius in rabbits. similar to that by  etorphine  0.05 vg/kg  or fentanyl  0.5 vg/kg. These inhibitions were reversed by naloxone. The respiratory inhibition induced by ohmefentanyl was less than that by fentanylp at the equal analgesic effect.
%U http://www.chinaphar.com/article/view/8629
%V 9
%N 4
%P 296-299
%@ 1745-7254