@article{APS8629,
author = {Jie Zhou and Wei-Jun Zheng and Zhi-Qiang Chi},
title = {Effect of ohmefentanyl injection to the region of nucleus tractus solitarius on discharge of phrenic nerve in rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {4},
year = {2016},
keywords = {},
abstract = {OhmefentanyI,N-I-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperdyl-N-phenylproanamide. is a potent analgesic first synthesized in our institute. Its main side-effect is respiratory inhibition. The discharge frequency of phrenic nerve was depressed about 50% by ohmefentanyl 0.02 vg/kg injected into the region of the nucleus tractus solitarius in rabbits. similar to that by etorphine 0.05 vg/kg or fentanyl 0.5 vg/kg. These inhibitions were reversed by naloxone. The respiratory inhibition induced by ohmefentanyl was less than that by fentanylp at the equal analgesic effect.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8629}
}