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Liver specific Iipoprotein-induced autoimmune hepatitis in mice

	author = {Peng-Peng Zhu and Xiao-Yu Li},
	title = {Liver specific Iipoprotein-induced autoimmune hepatitis in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Autoimmune  hepatitis  is a kind of chronic.  progressive liver injury which is characterized by the presence of several kinds of circulating liver membrane autoantibodies such as anti-LSP (liver specific  lipoprotein).  In this  study. mice autoimmune hepatitis was induced by repeated sc  immunization  with heterogeneic and syngeneic LSP which was prepared by ultra-centrifugation and chromatography of liver homogenates.  Serum high titer anti-LSP was detected by ELISA in C57BL mice immunized with rabbit LSP after l0-15wk. Human hepatitis B vaccine 25 ng/mouse sc once a week was given with LSP to accelerate the formation of liver injuries for 4 wk.  Liver  histological  changes revealed mainly  the mononuclear cell infiltration. pericholangitis and hepatocellular piecemeal necrosis which were mimic to human chronic active hepatitis. When using of Con A and 2'-deoxyguanosine as Ts inhibitors challenged together with syngeneic LSP in C57BL and JCR mice. the degree and number of mice with liver damages increased and was observed only after 3 wk. These results suggested that clinical hepatitis B virus infection and T disfunction may potentiate liver autoimmune reactions.},
	issn = {1745-7254},	url = {}