TY - JOUR AU - Lampa Enrico AU - Cazzola Mario AU - Angrisani Maurizio AU - Matera Concetta AU - Lisa Michele AU - Susanna Vincenza AU - Marrazzo Rosanna AU - Chieppa Savino AU - Marmo Emilio PY - 2016 TI - Cardiovascular effects of intracerebral injections of glutamate and kainate in rats JF - Acta Pharmacologica Sinica; Vol 9, No 3 (May 1988): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The intracerebral (lateral ventricle, 3rd ventricle, posterior hypothalamus and corpus striatum) administrations of sodium glutamate (G) 0.1-10 mg/rat and kainic acid (K) 0.1-10 Ug/rat induced transitory and dose-dependent increases of arterial BP and bradycardia. These effects were abolished by icv L-glutamic acid diethyl ester hydrochloride l-10 Ug/rat. G-and K-hypertensions were reduced by catecholamine depletion, peripheral adrenergic blocks, central a2-adrenergic stimulation, Ca2+ transmembrane block, ganglionic block, adrenalectomy, and spinal transection. Bilateral vagotomy and carotid sinus denervation augmented the hypertension. The bradycardia seemed to be reflexly mediated via carotid sinus and aortic pressoreceptors. UR - http://www.chinaphar.com/article/view/8617