%0 Journal Article %T Cardiovascular effects of intracerebral injections of glutamate and kainate in rats %A Lampa Enrico %A Cazzola Mario %A Angrisani Maurizio %A Matera Concetta %A Lisa Michele %A Susanna Vincenza %A Marrazzo Rosanna %A Chieppa Savino %A Marmo Emilio %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Cardiovascular effects of intracerebral injections of glutamate and kainate in rats %K %X The intracerebral (lateral ventricle, 3rd ventricle, posterior hypothalamus and corpus striatum) administrations of sodium glutamate (G) 0.1-10 mg/rat and kainic acid (K) 0.1-10 Ug/rat induced transitory and dose-dependent increases of arterial BP and bradycardia. These effects were abolished by icv L-glutamic acid diethyl ester hydrochloride l-10 Ug/rat. G-and K-hypertensions were reduced by catecholamine depletion, peripheral adrenergic blocks, central a2-adrenergic stimulation, Ca2+ transmembrane block, ganglionic block, adrenalectomy, and spinal transection. Bilateral vagotomy and carotid sinus denervation augmented the hypertension. The bradycardia seemed to be reflexly mediated via carotid sinus and aortic pressoreceptors. %U http://www.chinaphar.com/article/view/8617 %V 9 %N 3 %P 252-258 %@ 1745-7254