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Cardiovascular effects of intracerebral injections of glutamate and kainate in rats

   
@article{APS8617,
	author = {Enrico Lampa and Mario Cazzola and Maurizio Angrisani and Concetta Matera and Michele Lisa and Vincenza Susanna and Rosanna Marrazzo and Savino Chieppa and Emilio Marmo},
	title = {Cardiovascular effects of intracerebral injections of glutamate and kainate in rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The intracerebral (lateral ventricle, 3rd ventricle, posterior hypothalamus and corpus striatum) administrations of sodium glutamate (G) 0.1-10 mg/rat and kainic acid (K) 0.1-10 Ug/rat induced transitory and dose-dependent increases of arterial BP and bradycardia. These effects were abolished by icv L-glutamic acid diethyl ester hydrochloride l-10 Ug/rat. G-and K-hypertensions were reduced by catecholamine depletion, peripheral adrenergic blocks, central a2-adrenergic stimulation, Ca2+ transmembrane block, ganglionic block, adrenalectomy, and spinal transection. Bilateral vagotomy and carotid sinus denervation augmented the hypertension. The bradycardia seemed to be reflexly mediated via carotid sinus and aortic pressoreceptors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8617}
}