TY  - JOUR
AU  - Li Chun-Guang
AU  - Fu Shao-Xuan
AU  - Li Yun-Shan
AU  - Xu Yan-Fang
PY  - 2016
TI  - Histamine contents in hearts and whole blood during early myocardial ischemia in 3 rodents
JF  - Acta Pharmacologica Sinica; Vol 9, No 3 (May 1988): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Release of cardiac  histamine (H) by coronary artery ligation (CAL) in anesthetized dogs initiated early ischemic arrhythmias. Our purpose was to determine whether the H contents (by fluorospectrophotometric determination) in heart and whole blood were altered by CAL in anesthetized rats, guinea pigs and rabbits. The myocardial H contents in ischemic zone of left ventricle were decreased in these rodents 20 min after CAL. While the H concentration in the whole blood increased in rats. but not in other 2 species. The cardiac H contents were decreased by 42, 25 and 23% in rats.  guinea  pigs and rabbits, respectively. Thus, cardiac  H changes  induced  by  myocardial ischemia were different among rodents and  rats seemed  to be more  sensitive than rabbits and guinea pigs.
UR  - http://www.chinaphar.com/article/view/8613