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Absorbtion, distribution and excretion of gallanilide in rats and bioavailability in rabbits

  
@article{APS8600,
	author = {Duan Li and Ming Zhu and Xiang-Yuan Yang and Zhen-Yue Wang and Lu Li and Shi-You Yang and Qiu-Ming Chu and Xue-Ning Chen},
	title = {Absorbtion, distribution and excretion of gallanilide in rats and bioavailability in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Gallanilide 20 mg/kg iv in rats showed its  distributing  levels as follows: high in lung and kidney; spleen, gastrointestinal tract, liver,  heart, testis and blood  the next;  brain  the  least.  It  folloxved a pattern or two-compartment model in rat. After 20 mg/kg im  over  a  24-h  period, 2.4% of the dose was found in the urine. 0.08% in the feces, and 0.15% in bile excretion 5 h after iv 20 mg/kg. The ig (introgastric)  and  ir (rectal)  absolute bioavailability  of gallanilide  was 19 and 28% respectively, while the relative bioavailability  was  67% (p},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8600}
}