TY - JOUR AU - Xiong Wen-Cheng AU - Yan Jing-Chu PY - 2016 TI - Effects of eleven muscarinic drugs on trachea and ileum of guinea pig in vitro JF - Acta Pharmacologica Sinica; Vol 9, No 2 (March 1988): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The effects of eleven muscarinic subtype selective agonists and antagonists were observed on isolated trachea and lieum of guinea pig. The pAz values (against CCh) of 4-DAMP and AF-DX 116, both being putative M2 antagonists, were 9.04 and 5.9 on the ileum, and 6.94 and 6.70 on the trachea, respectively. The pAz values (against CCh) of gallamine, a neuromuscular blocker, were 5.40 and <3 on the trachea and ileum, respectively. The pAz values (against CCh) of pirenzepine, a putative M1 antagonist, on the ileum and trachea were similar, being around 6.80. These results suggest that the muscarinic receptors of trachea and ileum may not be homogeneous. UR - http://www.chinaphar.com/article/view/8582