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Potentiating effect of clonidine on the anxiolytic action of diazepam in rat social interaction model of anxiety

   
@article{APS8579,
	author = {Xiao-Min Yang and Zhi-Pu Luo and Jin-Huang Zhou},
	title = {Potentiating effect of clonidine on the anxiolytic action of diazepam in rat social interaction model of anxiety},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Pairs of Cr rats were placed in a test box under different illumination for 1O min and the time they spent in the active social interaction were scored. It was found  that  clonidine  (Clo)  3 vg/kg  and diazepam (Dia) 0.03 mg/kg ip 5d prior to the test and then ip 30 min before the test, did not alter the active interaction time (AIT). However, Clo 10 vg/kg and Dia 0.3 mg/kg prolonged the AIT. Clo 3 Vg/kg, ip 10 min before Dia 0.03 mg/kg, increased the effect of Dia on the AIT. Our results indicate that Clo potentiates the anxiolytic effect of diazepam in the social interaction model of anxiety.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8579}
}