%0 Journal Article
%T Inhibitory regulations of ohmefentanyl and morphine on postsynaptic dopamine receptors
%A Yao Yi-He
%A Chi Zhi-Qiang
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Inhibitory regulations of ohmefentanyl and morphine on postsynaptic dopamine receptors
%K 
%X Ohmefentanyl, a highly selective agonist for u opioid  receptors,  produced  a naloxone-reversible inhibition of amphetamine-induced  ipsilateral and apomorphine-induced contralateral rotation in rats with 6-hydroxy-dopamine-induced  unilateral lesion of nigrostriatal neurons. Acute treatments of ohmefentanyl and morphine decreased dopamine receptor density and inhibited the enhanced binding of [3H]spiperone to rat striatal dopamine receptors induced by denervation. It is proposed that these two  drugs probably have an indirect inhibitory  effect  on postsynaptic dopamine receptors in rat striatum.
%U http://www.chinaphar.com/article/view/8555
%V 9
%N 1
%P 15-18
%@ 1745-7254