%0 Journal Article %T Mutagenicity and teratogenicity of furapyrimidone %A Ni Yi-chang %A Shao Bao-ruo %A Zhan Chong-qing %A Xu Yue-qin %A Ha Shu-hua %A Jiao Pei-ying %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Mutagenicity and teratogenicity of furapyrimidone %K %X Furapyrimidone, a new effective antifilarial agent. was studied in Salmonella/microsome system for mutagenicity and in rats for teratogenicity. The mutagenic effect was quantitativejy assayed on 5 histidine-requiring strains of Salmonella typhimurium with and without activation by rat liver microsomes. The concentrations tested were 0.01-10 Vg/plate. In teratogenicity assay. the drug was given p0 140. 210. 280 mg/kg. qd x 5 d beginning on d 7 0f gestation.The results showed that furapyrimidone exhibited a potent mutagenic effect on TA 100 and TA 98 at 0.1 and I Vg/plate, respectively. The drug increased the number of dead fetuses and the rate of incomplete ossification of fetal sternum. %U http://www.chinaphar.com/article/view/8527 %V 4 %N 3 %P 201-205 %@ 1745-7254