@article{APS8508,
author = {Wei-xing Yao and Da-chao Fang and Jiao-Iing Zhao and Ming-xing Jiang},
title = {Effects of tetrandrine on contractility of isolated rat uteirus},
journal = {Acta Pharmacologica Sinica},
volume = {4},
number = {2},
year = {2016},
keywords = {},
abstract = {The isolated rat uterus con-traction induced by oxytocin and Ca++ after high-K+depolarization were markedly inhibited by tetrandrine (Tet). The depression was immediately reversed by addition of Ca++ to the bath fluid. Tet and verapamil (Ver), which shifted the cumulative dose-response curves to the right and depressed the maximal responses to CaCl2, acted as a non-competitive antagonist. The oxytocin-induced Cat+-dependent contractions were depressed by 4.8 and 30 uM Tet. Tet 30 uM also inhibited the Cat+-dependent component of the contraction. The effect of Ver on isolated rat uterus was stronger than that of Tet. Up to 0.05 uM, it showed no effect on Ca++-dependent oxytocin contraction. These results indicate that Tet is an effective Ca++-antagonist very similar to Ver on isolated rat uteri.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8508}
}