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Anti-aconitinic effects of caci2 and atropine

	author = {Shi-fang Liu and Yu-zhang Yang},
	title = {Anti-aconitinic effects of caci2 and atropine},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {In anesthetized rabbits con-tinuous iv infusion of 0.05% aconitine 0.06-0.08 mg/kg  slowed  the  respiration rate  significantly  for  about  10 s,  while 0.33-0.35 mg/kg  decreased  the  depth  of breathing by 50%.     Slow  iv  of  CaClz . 200 mg/kg  antago-nized the fibrillating effect of aconitine on guinea pigs and its respiratory depression action on rabbits. The LDso curve of CaCl2 was parallel to that of aconitine. CaCl2 (ip 2/5 LD60/kg) increased the LD60 0f aconitine t0 1.55-fold.    Atropine increased the LD60 0f aconi-tine or CaClz. Atropine and CaC12 used in combination increased the LD60 0f aconi- tine no more than they did separately. At.ropine counteracted the antagonistic effect of CaC12 against the shallow respi-ration caused by large dose of  aconitine (0.33-0.35 mg/kg).},
	issn = {1745-7254},	url = {}