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Antl-arrhythmic action of eimetidine

	author = {Shao-xuan Fu and Yun-shan Li},
	title = {Antl-arrhythmic action of eimetidine},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {In anesthetized rats, cimeti-dine (CMT) 120 mg/kg iv significantly in-creased the doses of aconitine required to induce arrhythmia and death; the incidence of ventricular fibrilliation and mortality due to iv CaC12 144 mg/kg were decreased by  CMT 60 and  120 mg/kg iv.   The ar-thythmias induced by iv BaC12 240 Vg/min and by coronary occlusions in rats were also counteracted by iv CMT 75 and 120 mg/kg, respectively.     In anesthetized rabbits, iv CMT 37.5 mg/kg delayed the onset of ventricular ec-topic beats and shortened the total du-ration of arrhythmia induced by iv ad-renaline 75 ug/kg.     The doses of ouabain necessary to in-duce ventricular extrasystole and death were elevated by iv CMT 3.75 mg/kg.min-1 in anesthetized guinea pigs.     The effective refractory period (ERP) of isolated rabbit left atria was prolonged significantly by CMT 0.225 and  0.45 mg/ml without affecting myocardial contrac-tility.},
	issn = {1745-7254},	url = {}