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Central machanisms involved l~l anti-arrhythmic action of vanilol

   
@article{APS8499,
	author = {Ji-gao Xiao and Xiao-ru Yuan and Xin Chen and Tian-pei Liu},
	title = {Central machanisms involved l~l anti-arrhythmic action of vanilol},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {After the right stellate ganglion of anesthetized rabbits was excised electrical stimulation of the posterior hy-pothalamus consistently resulted in an ar-thythmia with hypertension and mydria-sis. The arrhythmia was prevented by iv vanilol   (1- ( 2-methoxy-4-methoxycarbon-yl-l-phenoxy) -3-isopropylamino-2-pro-panol) 10 mg/kg, aminosteroid 5.0 mg/kg, cyclovirobuxine  D (CV.B)  2.0 mg/kg. di-phenylhydantoin  (DPH)  30 mg/kg  or in-travertebrally (ia) DPH 3 mg/kg.  Vanilol J mg/kg ia prevcnted the arr-hythmia in 15/18 0f the rabbits (8326), but ia amino-steroid, CVB and propranolol did not. These results suggest that the antiarrhy-thmic action of vanilol against central neurogenic arrhythmia is within the CNS besides its direct action on the heart.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8499}
}