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Spasmolytic actions of active principles of volatile oil of acorus gramineus

	author = {Guo-qing Liu and Jian-ning Sun and Zheng-zheng He and Yin Jiang},
	title = {Spasmolytic actions of active principles of volatile oil of acorus gramineus},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Three active principles, a-asarone (1), [3-asarone (Il) and l-allyl-2,4, 5-trimethoxybenzene (III), obtained from Acorus gramineus were found to possess spasmolytic action on isolated guinea pig's trachea and ileum against the spasmogenq acetylcholine (ACh), histamine (Hist), se-rotonin (5-HT), and BaClz. Out of these 3 compounds, I was most effective with the minimal effective concentrations of lO ug/ml against ACh,Hist and 5-HT on trachea; 10 ht9/ml  against  ACh, 20 ug/ml  against Hist, 10 ug/ml  against  5-HT,  and 80 ug/ml against BaCl2 0n ileum. The concentra-tions of I for complete blocking action against  spasmogens were 40 u. g/ml against ACh, 80 Vg/ml against Hist, and  53 ug/ml against 5-HT  on  trachea. II andⅢ were less potent than l.  Dandiya et al reported in 1964 that I (3 0r 6mg/kg) possessed many neuropharmacological properties similar to chlorpromazine and reserpine. These properties were not reproduced even with the doses  of 24 and  48 mg/kg  in our laboratory except I potentiated  pentobar-bital-induced hypnosis.},
	issn = {1745-7254},	url = {}