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Central effects of anisodamine, atropine, anisodine and scopolamine after intraventricular injection

	author = {Jian-zhong Peng and Li-rong Jin and Xian-yu Chen and Zeng-xing Chen},
	title = {Central effects of anisodamine, atropine, anisodine and scopolamine after intraventricular injection},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Anisodine and  anisodamine are new tropine alkaloids isolated from Scopolia tangutica. The chemical structure of anisodine is different from scopolamine by a hydroxy group on the tropine acid moiety. Anisodamine is different from atropine by a hydroxy group on the 6th position of tropine.     In unanesthetized rabbits, intracere-broventricular(icv) injection of anisodin e-HBr 2.4mg/kg or' scopolamine-HBr 0.8 mg/kg produced a  high synchronization and blocked the EEG arousal response. Rabbits became quiet.  5-10 min  after  icv anisodamine-HBr  l-2 mg/kg  or  atropine sulfate 0.25-1mg/kg, cerebral electrical activity showed a low amplitude and a fast frequency, follovred by frequent spikes and seizure discharges. .The rabbits appeared excited with tachypnea, nystagmus and clonic convulsion. It suggests that aniso-dine and scopolamine are mainly CNS de-pressants; anisodamine and atropine are mainly stim ulants.      Intravenous (iv) injections of 4 tro-pine alkaloids induced a high synchroni-zation and blocked the EEG arousal re-sponse in rabbits. Effects of anisodamine and atropine on EEG and the behavior of rabbits depended on the route of admini-stration.     In mice icv of these tropine alkaloids produced similar behavioral effects as in rabbits. Physostigmine, pilocarpine, ani-sodine, mecamylamine, reserpine, chlorpro-mazine, 5-HTP, glycine, picrotoxin, caf-feine and pentobarbital did not affect CD60 0f anisodamine and atropine. But ip diazepam  (5-20 mg/kg)  significantly  in-creased CD60. This suggests that central stimulation by anisodamine and atropine may be related to the mechanism modula-ting the GABA-ergic function.},
	issn = {1745-7254},	url = {}