@article{APS8487,
author = {Roger P Maickel and Janell Seeger and Wayne R Snodgrass},
title = {Physiological disposition of iproniazid in mice},
journal = {Acta Pharmacologica Sinica},
volume = {4},
number = {1},
year = {2016},
keywords = {},
abstract = {The time-course of [14Clipro_niazid was followed for 96 h after admin-istration of a single dose (ip) to mice on either control or pyridoxine-deficient diets. Pharmacokinetic data showed an a-decay phase in plasma and tissues of 0.5-1.Oh and β-decay phases ranging from 13.5 t0 47.5 h. The β-phase half-lives in mice on the pyridoxine-deficient diets were decreased in plasma and kidneys and in-creased in liver,as compared to control diet animals. Covalent binding of iproniazid to liver proteins was increased in mice on the pyridoxine-deficient diet.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8487}
}