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Physiological disposition of iproniazid in mice

	author = {Roger P Maickel and Janell Seeger and Wayne R Snodgrass},
	title = {Physiological disposition of iproniazid in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The time-course of [14Clipro_niazid was followed for 96 h after  admin-istration of a single dose (ip) to mice on either control or pyridoxine-deficient diets. Pharmacokinetic data showed an a-decay phase in plasma and tissues of 0.5-1.Oh and β-decay phases ranging from 13.5 t0 47.5 h. The β-phase  half-lives in mice on the pyridoxine-deficient diets were decreased in plasma and kidneys and in-creased in liver,as compared to control diet animals. Covalent binding of iproniazid to liver proteins was increased in mice on the pyridoxine-deficient diet.},
	issn = {1745-7254},	url = {}