How to cite item

Effect in vitro of metabolites of praziouantel on schistosoma japonicum

	author = {Feng-xiang Wang and Yan-qin Zhu and Quan-sheng Yao and Han-ying Yan and Shang-ren Pan and Wei-yi Li and Ying-ying Feng},
	title = {Effect in vitro of metabolites of praziouantel on schistosoma japonicum},
	journal = {Acta Pharmacologica Sinica},
	volume = {4},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The metabolites of prazi-quantel were studied in  urine of patients infested with Schistosoma japonicum and healthy rats. The patients were given oral-ly praziquantel 30 mg/kg/d x2 d  and  the metabolites in urine were isolated by non-ionic resin extraction techniques. Crys-tal-l thus obtained was subjected to UV-visible absorption, IR and mass spectrum analysis. The chemical structure of crys-tal-l appears as follows.    In rats, after po [14C]pra_ziquantel, 6 metabolites  (ui-uo) were isolated from the urine by TLC and radioautography.     Among these metabolites, crystal-l, u3, u4, and u6 showed various degrees of antischistosomal activity in vitro, but less active than praziquantel.},
	issn = {1745-7254},	url = {}