%0 Journal Article
%T Effects of estrogen on gastrocnemius muscle strain injury and regeneration in female rats
%A FENG Xin
%A LI Guo-zhen
%A WANG Sheng
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Effects of estrogen on gastrocnemius muscle strain injury and regeneration in female rats
%K 
%X AIM:  To study the effects of estrogen on muscle damage and regeneration after acute passive gastrocnemius muscle strain injury in female Sprague-Dawley rats.  METHODS:  Rats were divided into 5 groups: ovariectomized, strained and treated with low-dosage estradiol (20 microg/d) (E(low)), treated with high-dosage estradiol (200 microg/d) (E(high)), treated with oil placebo (Oil), strained with no ovariectomy (Strain), and sham operated with no strain and no ovariectomy (Con). Muscle damage index [plasma creatine kinase (CK)], antioxidant indexes [glutathione (GSH), Vitamin E (Vit E), total antioxidant capability (TAC)], and muscle regeneration index (desmin) were investigated at 7 d.  RESULTS:  The plasma CK activity increased but GSH, Vit E, and TAC levels decreased after muscle strain injury (Strain vs Con P
%U http://www.chinaphar.com/article/view/8411
%V 25
%N 11
%P 1489-1494
%@ 1745-7254