@article{APS8391,
author = {Yu-ping PENG and Yi-hua QIU and Jian-lan JIANG and Jian-jun WANG},
title = {Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM:
To explore effects of exogenous and endogenous catecholamines on function of lymphocytes and primary mechanisms mediating the effects.
METHODS:
Splenocytes of rats were exposed to norepinephrine (NE), alpha- or beta-adrenoceptor antagonists plus NE, or alpha-methyl-p-tyrosine (alpha-MT), and then concanavalin A (Con A)-induced interleukin-2 (IL-2) production and natural killer (NK) cell cytotoxicity were determined by MTT assay and LDH assay, respectively.
RESULTS:
Optical density (OD) values of NE-treated groups, which reflected IL-2 production, were 0.63, 0.61, and 0.60, respectively for 10(-10), 10(-9), and 10(-8) mol/L NE. They were all significantly reduced in comparison with control value of 0.68 (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8391}
}