@article{APS8342,
author = {Fernando Rodriguez de Fonseca and Amanda J Roberts and Ainhoa Bilbao and George F Koob and Miguel Navarro},
title = {Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {12},
year = {2016},
keywords = {},
abstract = {AIM:
To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration.
METHODS:
We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers.
RESULTS:
Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A.
CONCLUSION:
These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8342}
}