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Comet electrophoresis of blood nucleated cells in genotoxicity assessment.

   
@article{APS8302,
	author = {Ju-yuan Guo and Zeng-hong Tu},
	title = {Comet electrophoresis of blood nucleated cells in genotoxicity assessment.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {AIM:
Genotoxicity evaluations of several different chemicals including L-4-oxalysine, 10-Hydroxycamptothecin (HCT), 19-norprogesteron (ST1435), dimethyl sulfoxide (Me2SO), bleomycin (BLM), and mitomycin C (MMC).
METHODS:
Alkaline comet assay in vitro (single cell gel) (SCG).
RESULTS:
L-4-oxalysine and HCT did not cause directly DNA damage. ST1435, the subdermal implant progestin, had no effect on DNA damage until the dose level up to 4 mmol.L-1. Me2SO did not increase DNA damage at concentration below 2%, but showed a concentration-dependent DNA damage at > or = 4%. Bleomycin and mitomycin C demonstrated a strong dose-dependent DNA damage.
CONCLUSION:
Comet assay as a tool to test the genotoxicity of suspected chemicals, is rapid, simple, sensitive, good reproducible, and inexpensive.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8302}
}