@article{APS8287,
author = {Hong-wei Zhao and Xiao-yu Li},
title = {Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM:
To study the effects of ginkgolide A, B (Gin A, Gin B) and huperzine A (Hup A) on nitric oxide (NO) production from cultured astrocytes.
METHODS:
Nitrites in supernatants were measured with Griess assay.
RESULTS:
Hup A 0.001-100 mumol.L-1 time- and concentration-dependently inhibited the NO production from rat C6 astrocytoma cells. The NO production from C6 cells was concentration-dependently inhibited by the treatment with Gin A or Gin B 0.001-10 micromol.L-1 for 24 h. The NO production from human BT325 astrocytoma cells was concentration-dependently inhibited by Hup A, Gin A, or Gin B 0.01-10 micromol.L-1 for 24 h.
CONCLUSION:
Gin A, Gin B, and Hup A inhibited astrocytes producing NO.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8287}
}