@article{APS8239,
author = {Hong-jie Zhou and Hai-di Li and Xi-cheng Li and Huai-zhen Ruan and Bang-yun Zhao},
title = {Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia.},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {8},
year = {2016},
keywords = {},
abstract = {AIM:
To study the effects of corticotropin (Cor) on formalin-induced hyperalgesia and the change of nitric-oxide synthase (NOS)-positive neurons in spinal dorsal horn in rats.
METHODS:
Measurement of pain intensity rating (PIR), NADPH-d histochemistry, and Fos immunohistochemistry were adopted.
RESULTS:
The increases of NOS-positive neurons, Fos, NOS/Fos double labelling neurons of the spinal dorsal horn and the PIR after formalin injection were markedly inhibited by intrathecal injecting (ith) Cor (0.5-1.5 U), which were obviously attenuated by L-arginine (Arg, 5-15 nmol, ith), the substrate of NOS.
CONCLUSION:
Cor inhibits formalin-induced hyperalgesia by the decrease of NOS-positive neurons in the spinal dorsal horn of rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8239}
}