%0 Journal Article %T Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia. %A Wang Zhong-feng %A Xue Chun-sheng %A Zhou Qi-xin %A Wan Zi-bing %A Luo Quan-sheng %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia. %K %X AIM: To study the effects of tetrandrine (Tet) on the changes of NMDA receptor channels in cortical neurons induced by anoxia. METHODS: Cell-attached configuration of patch-clamp techniques. Anoxia was produced by perfused cells with 95% N2 + 5% CO2 gassed bath solution. RESULTS: During anoxia, the open time constant (tau 2), open probability (Po) of 35-pS and 100-pS channels increased. Tet 7.5 mumol.L-1 reduced the Po of 35-pS and 100-pS channels, 15 and 30 mumol.L-1 inhibited open of 100-pS channel fully, and changed the open time constant of 35-pS from two to single exponential distribution. CONCLUSION: Tet inhibition of the open of NMDA receptor channels induced by anoxia was one of its protective mechanisms. %U http://www.chinaphar.com/article/view/8236 %V 20 %N 8 %P 729-732 %@ 1745-7254