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Subtypes of central nicotinic receptors involved in learning and memory.

   
@article{APS8234,
	author = {Li-jun Chen and Ru-zhu Chen},
	title = {Subtypes of central nicotinic receptors involved in learning and memory.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {8},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To observe the effects of different subtypes of central nicotinic receptor on learning and memory.
METHODS:
Passive avoidance response, including step-down avoidance and step-through avoidance in mice and long-term potentiation (LTP) in rat hippocampal slices.
RESULTS:
Hexamethonium (C6) 7 micrograms/mouse and kappa-bungarotoxin (kappa-BTX) 0.6 microgram/mouse inhibited the acquisition of avoidance conditioning in mice, and kappa-BTX yielded this effect with a dose-response relationship. kappa-BTX 1 mumol.L-1 suppressed the induction of LTP (P < 0.05), but not normal synaptic transmission and maintenance of LTP in rat hippocampal slices.
CONCLUSION:
The subtypes of central nicotinic receptor sensitive to kappa-BTX play an important role in learning and memory.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8234}
}