@article{APS8213,
author = {Qin-gui XIA and Alexander REINECKE and Marc DORENKAMP and Christain STORZ and Havvo BITTERLING and Susanne PENZ and Jack CLEUTJENS and Mat JAP DAEMEN and Reichiger SIMON and Thomas UNGER},
title = {Comparison of cardioprotective effects of mibefradil and ramipril in stroke-prone spontaneously hypertensive rats},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM:
To elucidate the cardioprotective effects of T-type calcium channel blocker mibefradil and compare with that of the angiotensin-converting enzyme inhibitor ramipril in a stroke-prone spontaneously hypertensive rats (SHR-SP) model of congestive heart failure (CHF) after myocardial infarction (MI).
METHODS:
SHR-SP rats were subjected to permanent ligation of the left anterior decending coronary artery. Treatment with mibefradil (10 mg.kg(-1).d(-1)), ramipril (10 mg.kg(-1).d(-1)), or placebo was initiated 4 weeks before surgery and continued up to 6 weeks after induction of MI. Sham-operated rats served as controls.
RESULTS:
In placebo-treated MI rats, six weeks after MI, left ventricular circumference, inner diameter, and left ventricular end-diastolic pressure (LVEDP) were increased, whereas mean arterial blood pressure (MAP) and maximum rate of rise of left ventricular pressure (dp/dt(max)) were decreased compared with sham-operated controls (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8213}
}