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Toosendanin increases free-Ca(2+) concentration in NG108-15 cells via L-type Ca(2+) channels

   
@article{APS8188,
	author = {Tong-hui XU and Jun ding and Yu-liang SHI},
	title = {Toosendanin increases free-Ca(2+) concentration in NG108-15 cells via L-type Ca(2+) channels},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To examine if toosendanin (TSN) affects intracellular free-Ca(2+) concentration ([Ca(2+)](i)) in neuroblastoma pluglioma hybrid cells (NG108-15 cells).
METHODS:
The [Ca(2+)](i) was determined by laser-scanning confocal microscopic imaging technique in which Fluo-3 was used as Ca(2+) indicator.
RESULTS:
TSN induced an increase in resting [Ca(2+)](i) and in high K(+)-evoked Ca(2+) transient in differentiated NG108-15 cells. The TSN-induced increase in [Ca(2+)](i) was dose-dependent and disappeared in CdCl(2-), nifedipine-containing or Ca(2+)-free solution, and appeared after washing out the Ca(2+) channel blockers or adding Ca(2+).
CONCLUSION:
TSN increased [Ca(2+)](i) in differentiated NG108-15 cells. The [Ca(2+)](i) enhancement was due to the influx of extracellular Ca(2+) and related to L-type Ca(2+) channels.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8188}
}