@article{APS8171,
author = {Wan-Bin Liu and Guo-Qing Liu and Hang Xiao and Xia Mao and Yun Shi and Jian-Ping Wu},
title = {Tetrandrine inhibits inward rectifying potassium current in cultured bovine aortic endothelial cells},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {12},
year = {2016},
keywords = {},
abstract = {\"AIM:
To study the effect of tetrandrine (Tet) on inward rectifying potassium current in cultured bovine aortic endothelial cells.
METHODS:
Inward rectifying potassium current (IRK) was observed by the whole cell patch-clamp technique.
RESULTS:
IRK was inhibited by Tet in a concentration-dependent manner and recovered to normal after wash with drug-free external solution. IRK was reduced from (582 +/- 48) pA to (221 +/- 40) pA at a holding potential of -70 mV by Tet 30 mumol/L. IC50 was 2.8 mumol/L.
CONCLUSION:
Tet inhibited inward rectifying potassium current in cultured bovine aortic endothelial cells.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8171}
}