%0 Journal Article %T G-2964A and C734A genetic polymorphisms of CYP1A2 in Chinese population %A Han Xing-Mei %A Chen Xiao-Ping %A Wu Qi-Nan %A Jiang Chang-Hong %A Zhou Hong-Hao %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! G-2964A and C734A genetic polymorphisms of CYP1A2 in Chinese population %K %X "AIM: To observe the G-2964A and C734A genetic polymorphisms of human CYP1A2 in Chinese population. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed in genotyping analysis. RESULTS: The allele frequencies of A-2964 were 0.25 and 0.22 in Qidong and Changsha populations, respectively. The incidences of A734 were 0.68 in Qidong population and 0.66 in Changsha population. No more than two low-inducibility/activity alleles were presented in one person. CONCLUSION: The distribution of the G-2964A and C734A genetic polymorphisms did not show significant difference between Chinese and Japanese populations. The incidence of C734A in Chinese was also similar to that in Caucasian population." %U http://www.chinaphar.com/article/view/8158 %V 21 %N 11 %P 1031-1034 %@ 1745-7254