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Blocking effect of tricyclopinate on nicotinic receptors in cultured sympathetic neurons

   
@article{APS8155,
	author = {Jian-Quan Zheng and Xiang-Ping He and Ai-Zhen Yang and Chuan-Gui Liu},
	title = {Blocking effect of tricyclopinate on nicotinic receptors in cultured sympathetic neurons},
	journal = {Acta Pharmacologica Sinica},
	volume = {21},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {\"AIM:
To investigate the mechanism of tricyclopinate, an antagonist of nicotinic receptor, on neuronal nicotinic acetylcholine receptors (nAChR).
METHODS:
A tight seal whole-cell recording patch-clamp technique was performed to record nicotine-evoked currents in the cultured sympathetic neurons from neonatal rat superior cervical ganglia (SCG).
RESULTS:
Tricyclopinate inhibited the nicotine-induced currents competitively and the inhibition was voltage-independent. The decay of the nicotine-induced current was accelerated significantly in the presence of tricyclopinate.
CONCLUSION:
Tricyclopinate inhibits neuronal nAChR by interacting with the allosteric sites rather than the open ionic channels or acetylcholine recognition site of the receptor.\"},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8155}
}