TY  - JOUR
AU  - Chen Zhen-Yu
AU  - Law Wai-Ip
AU  - Yao Xiao-Qiang
AU  - Lau Chi-Wai
AU  - Ho Water Kwok Keung
AU  - Huang Yu
PY  - 2016
TI  - Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells
JF  - Acta Pharmacologica Sinica; Vol 21, No 9 (September 2000): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - "AIM:  The present study was aimed to examine the vasorelaxant and antiproliferative responses to purified green tea epicatechin mixture, (-)epicatechin and (-)epigallocatechin gallate on rat arterial smooth muscle cells.  METHODS:  Changes in isometric force were measured by Grass force transducer and effects on cell proliferation were evaluated using [3H]thymidine incorporation assay.  RESULTS:  Epicatechin mixture, (-)epicatechin and (-)epigallocatechin gallate, which we isolated and purified from jasmine green tea, concentration-dependently, reduced the contractile response to phenylephrine in rat isolated aortic rings with (-)epigallocatechin gallate being more effective. These three agents also inhibited [3H]thymidine incorporation into DNA in cultured rat aortic smooth muscle cells in a concentration-dependent manner.  CONCLUSION:  The purified epicatechin derivatives from jasmine green tea relaxed the isolated rat arteries preconstricted by phenylephrine and inhibited aortic smooth muscle cell proliferation."
UR  - http://www.chinaphar.com/article/view/8112