%0 Journal Article
%T Facilitating effects of histamine on spatial memory deficit induced by scopolamine in rats
%A Chen Zhong
%A Kamei Chiaki
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Facilitating effects of histamine on spatial memory deficit induced by scopolamine in rats
%K 
%X "AIM:  To investigate whether or not histamine was involved in scopolamine-induced spatial memory deficits evaluated in 8-arm radial maze performance of rats.  METHODS:  Eight-Arm radial maze performance was used to measure spatial memory in rats, and the brain regions were subsequently dissected and histamine contents were determined by HPLC.  RESULTS:  Intracerebroventricular (icv) injection of histamine (100 or 200 ng) or thioperamide (50 micrograms), and intraperitoneal (i.p.) injection of histidine (1000 mg/kg) ameliorated memory impairment induced by scopolamine regarding both parameters of radial maze performance. 2-Thiazolylethylamine, but not 4-methylhistamine showed the similar effect to histamine. Both histamine (200 ng, icv) and histidine (1000 mg/kg, i.p.) were equally effective in increasing the histamine content in the cortex, hippocampus, and hypothalamus.  CONCLUSION:  These results suggest that brain histamine plays an important role in learning and memory, and its action may be due to cholinergic neurons."
%U http://www.chinaphar.com/article/view/8106
%V 21
%N 9
%P 814-818
%@ 1745-7254