@article{APS8089,
author = {Hai-Bo Zhu and Mei-Yu Geng and Hua-Shi Guan},
title = {Antihypertensive effects of D-polymannuronic sulfate and its related mechanisms in renovascular hypertensive rats},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {8},
year = {2016},
keywords = {},
abstract = {\"AIM:
To investigate the antihypertensive effects of D-polymannuronic sulfate (DPS), a kind of sulfated polysaccharide, and the underlying mechanisms in renovascular hypertensive rats (RHR).
METHODS:
Used two-kidney one clip (Goldblatt, 2-K 1C) method to produce RHR model. DPS was given i.v. or ig for 5 wk with the initiation of establishment of RHR. Serum nitric oxide (NO) was determined with NO kit; plasma angiotensin II (Ang II) and endothelin-1 (ET-1) were measured by radioimmumoassays.
RESULTS:
In acute therapeutic experiments, DPS markedly reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP) dose-dependently and decreased heart rate (HR) with reduction in arterial blood pressure. In the prophylactic experiments, DPS prevented the rise in SBP and DBP in a dose-dependent manner. The hypotensive potency of DPS 50 mg/kg is comparable to that of captopril (14 mg/kg). Moreover, DPS elevated serum NO contents and lowered plasma concentrations of Ang II and ET-1.
CONCLUSION:
The antihypertensive activities of DPS might be involved both in increasing the generation of nitric oxide and in decreasing the production of angiotensin II and endothelin-1 in vivo.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8089}
}