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D609 induces vascular endothelial cells and marrow stromal cells differentiation into neuron-like cells

   
@article{APS8054,
	author = {Nan WANG and Chun-qing DU and Shao-shan WANG and Kun XIE and Shang-li ZHANG and jun-ying MIAO},
	title = {D609 induces vascular endothelial cells and marrow stromal cells differentiation into neuron-like cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To investigate the effect of tricyclodecane-9-yl-xanthogenate (D609) on cell differentiation in vascular endothelial cells (VECs) and marrow stromal cells (MSCs).
METHODS:
Morphological changes were observed under phase contrast microscope. Electron microscope and immunostaining were used for VECs identification. The expressions of neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP) were examined by immunohistochemistry.
RESULTS:
After 6 h of induction with D609, some VECs showed morphological changes characteristic of neurones. 9 h later, more VECs became neuron-like cells. About 30.8% of VECs displayed positive NSE (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8054}
}