@article{APS8048,
author = {Can LI and Sun-woo LIM and Bo-kyung SUN and Bum-soon CHOI and Sylvia GLOWACKA and Alison J COX and Darren J KELLY and Yong-soo KIM and Jin KIM and Byung-kee BANG and Chul-woo YANG},
title = {Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM:
To examine whether the reversibility of chronic cyclosporine A (CsA) nephrotoxicity is associated with apoptotic cell death and its regulatory factors.
METHODS:
Chronic CsA nephrotoxicity was induced in Sprague-Dawley rats by administering CsA (15 mg/kg, sc) for 5 weeks, and then withdrawing it for 5 or 10 weeks. The effect of CsA withdrawal on apoptotic cell death was evaluated by an in situ TdT-mediated deoxyuridine triphosphate-biotin nick end-labeling (TUNEL) assay and the expression of pro-apoptotic [transforming growth factor-beta 1 (TGF-beta 1) and Fas] and anti-apoptotic [epidermal growth factors (EGF) and Bcl-2] factors.
RESULTS:
Discontinuation of CsA induced significant decreases in TUNEL-positive cells in a time-dependent manner and the reduction in TUNEL-positive cells was correlated with the tubulointerstitial fibrosis score (r=0.919, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8048}
}