%0 Journal Article %T Long-term potentiation induced by nicotine in CA1 region of hippocampal slice is Ca(2+)-dependent %A He Jin %A Deng Chun-Yu %A Chen Ru-Zhu %A Zhu Xiao-Nan %A Yu Jian-Ping %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Long-term potentiation induced by nicotine in CA1 region of hippocampal slice is Ca(2+)-dependent %K %X "AIM: To observe the effects of Ca2+ on hippocampal long-term potentiation (LTP) induced by nicotine in CA1 region of rat hippocampal slice. METHODS: Extracellularly recorded population spikes (PS) of the pyramidal cell layer in the hippocampal CA1 region in vitro. RESULTS: Nicotine 1 mumol.L-1 induced LTP in the hippocampal CA1 region. It did not induce LTP in CA1 region when CA2+ was removed from artificial cerebrospinal fluid (ACSF). Nifedipine 1 and 10 mumol.L-1 partly inhibited LTP induced by nicotine, and thapsigargin 1 and 10 mumol.L-1 completely inhibited LTP induced by nicotine. CONCLUSION: LTP induced by nicotine in hippocampal CA1 region is Ca(2+)-dependent. Both Ca2+ influx and Ca2+ release participate in the induction of LTP." %U http://www.chinaphar.com/article/view/8020 %V 21 %N 5 %P 429-432 %@ 1745-7254